INFN, ISS - Superior Institute of Health, CINECA - Interuniversity Consortium and SIT - Italian Telemedicine Society, which promoted the initiative, have entered into a collaboration agreement to promote, coordinate and carry out biomedical research using digital and telecommunication technologies in innovative ways. Specifically, the agreement envisages the study of new systems to manage information flows over the Internet for patient care and remote health care activities, the development and testing of new digital systems for telemedicine, digital therapies, tele-rehabilitation and digital medicine, and ways to personalise care, combining different digital technologies. The collaboration will also include the development and testing of new methods for analysing the complexity of biological systems, and the study and development of new digital systems for conducting clinical trials. These research initiatives serve to foster co-production mechanisms of digital innovations for medicine, but also to scientifically validate organisational models, protocols, processing and projects for new opportunities in medical science.